Avoid the area.
1:34pm Update: The Times Union reports a 29 year old man was seriously injured in the crash, he was taken to Albany Medical Center and is said to be in critical condition. A crash reconstruction team was on the scene to figure out the cause. Route 146 has since been reopened.
The Saratoga County Sheriff's Office is asking drivers to avoid Route 146 in Clifton Park between Route 146A and Tanner Road. Police say an accident has closed the road in both directions.